Orlistat is indicated in the management of overweight or obese patients with a body mass index (BMI) >30 kg/m2 or a body mass index >27 kg/m2, or with obesity-related conditions such as diabetes mellitus, and dyslipidaemia and fatty liver disease, in combination with a reduced-calorie diet. Orlistat is also indicated as adjunct to diet and exercise in the management of patients with gastric or duodenal ulcers in patients with a BMI >30 kg/m2 or a BMI >27 kg/m2 who have no improvement after 3 days of therapy with orlistat. Orlistat is indicated for patients with obesity-related conditions and dyslipidaemia, in combination with a reduced-calorie diet. Patients with the following conditions may be offered orlistat without discussion with their primary care physician: heart failure; heart failure in patients with a BMI >30 kg/m2; acute heart failure; acute worsening of chronic heart failure; acute worsening of chronic heart failure and/or worsening of chronic heart failure; acute worsening of heart failure; acute worsening of heart failure and/or worsening of chronic heart failure; patients with severe renal impairment; patients with severe hepatic impairment; or patients with active peptic ulceration and perforation of bowel movements. Orlistat is also indicated as adjunct to alcohol and illicit drug use in patients with a BMI >30 kg/m2 or a BMI >27 kg/m2 who have not improved after 3 days of therapy with orlistat. Patients with the following conditions may be offered orlistat without discussion with their primary care physician: kidney disease; patients with severe obesity, with or on high calorie diet; patients with the following conditions may be offered orlistat without discussion with their primary care physician: history of gastrointestinal bleeding; patients with the following conditions may be offered orlistat without discussion with their primary care physician: severe hepatic impairment; patients with the following conditions may be offered orlistat without discussion with their primary care physician: history of severe renal impairment; or patients with the following conditions may be offered orlistat without discussion with their primary care physician: history of severe hepatic impairment. Patients with the following conditions may be offered orlistat without discussion with their primary care physician: patients with a BMI >30 kg/m2 or a BMI >27 kg/m2 who have not improved after 3 days of therapy with orlistat, and patients with severe gastric or duodenal ulcer disease. Orlistat is also indicated for patients with the following conditions:
May be taken with or without food.
Hypersensitivity to the active substance, to the content of any glucagon-like peptide 1 (GLP-1) receptor agonist (e.g. semaglutide), or to any of the components of the drug; hypersensitivity to orlistat or to any of the excipients.
Glucagon-like peptide 1 (GLP-1) agonists are contraindicated in patients with a prior diagnosis of gastric or duodenal ulcer disease and/or gastrointestinal bleeding (see sections 3.2 and 3.4). Patients with a history of peptic ulcer disease should be carefully monitored and patients should be treated with caution. Patients with a history of seizure disorders should be observed for possible seizures. Patients should be closely monitored for the development of polyps, which can lead to the development of tumours in the duodenum (see section 3.2).
Some adverse reactions were observed in association with orlistat therapy in patients with a BMI >27 kg/m2 or a BMI >27 kg/m2 who have not improved after 3 days of therapy with orlistat. These reactions include: gastrointestinal symptoms (e.g. nausea, vomiting, anorexia, loss of appetite, weight loss, dry mouth, constipation, loss of appetite, dry mouth, dizziness, tinnitus, headache, lightheadedness, blurred vision, increased thirst, increased urination); increased body temperature; headache; decreased appetite; and weight gain, loss of appetite, or weight loss. In addition, some patients had an increase in triglycerides (see section 3.1).
Orlistat is used to treat obesity and help in weight loss. Orlistat is to be used along with a low-calorie diet and regular physical exercise. Obesity is a common condition associated with excessive body fat, which in turn increases the risk of other health problems such as diabetes, high blood pressure, certain cancers, and heart disease. Intake of more calories than you burn by exercise or daily activities results in obesity.
Orlistat contains Orlistat, which works in the small intestine and stomach and prevents the action of enzymes that break down fat, which is absorbed by the body. Orlistat decreases the absorption of fat from the food you eat. Thus, fat passes through the gut and is excreted in the faeces, which makes the body unable to use fat as a source of energy or convert it into fat tissue. Thereby, Orlistat helps in weight loss.
Take Orlistat as prescribed by your doctor. You are advised to take Orlistat for as long as your doctor has prescribed it for you based on your medical condition. Some people may experience soft stools, sudden bowel motions, flatulence (gas) with or without oily spotting, oily or fatty stools, stomach pain, stool incontinence (involuntary leakage of stools), and runny or liquid stools. Most of these side effects of Orlistat do not require medical attention and gradually resolve over time. However, if the side effects persist, please consult your doctor.
If you are allergic to Orlistat or any other medicines, please tell your doctor. Avoid taking Orlistat if you are pregnant or planning for pregnancy, as it may cause fetal harm. It is not known whether Orlistat is excreted in human milk. Therefore, please consult a doctor if you are a breastfeeding woman. Orlistat is not recommended for children below 18 years of age, as the safety and effectiveness were not established. You are advised to take a multivitamin containing fat-soluble vitamins such as A, D, E, and K at bedtime as Orlistat may reduce the absorption of certain vitamins in the body.
ContraindicationsOrlistat is not recommended for use in patients with a known hypersensitivity to orlistat or to any of the other ingredients of this medicine. Patients with severe liver or kidney problems, including patients with a history of giardiasis, asthma, or other allergic diseases should not take Orlistat. If Orlistat is used in patients with a history ofarenthood who are undergoing a history-based family history of anogenital events or in patients who are taking hormone replacement therapy, or in patients who are taking warfarin, a history of ovarian hyperstimulation syndrome, or endometrial hyperplasia, then Orlistat may not be recommended. Orlistat may increase the risk of developing allergies, particularly to other weight-related medicines. Orlistat should not be used in patients with a history of hepatic impairment, renal impairment, or severe asthma, with a history of urticaria, or in patients with history of obesity.
Orlistat is not recommended for use in patients should be pregnant or breastfeeding. Therefore, caution is exercised in elderly women, patients with a history of ovarian hyperstimulation syndrome, endometrial hyperplasia, or a history of any other pathology during or at the treatment of Orlistat. If you experience sudden bowel movements (stools) or bowel motions (stools), sudden bowel movements (stools), or flatulence (gas) or oily stools, please consult a doctor. In case you experience any of the following side effects, including black, tarry stools, flatulence, gas, leakage of stools, runny or liquid stools, or bowel motions, please consult a doctor.
Orlistat may cause unpleasant or allergic reaction, especially if you are allergic to any of the components. The most common side effects of Orlistat are nervousness, trouble sleeping, weakness, headache, dizziness, and diarrhea. Most of the time, these side effects are reversible and do not require medical attention. You are advised to stop taking Orlistat and seek medical attention as soon as you feel the effects of these side effects, as they may worsen. If you experience any side effects, please consult a doctor. If you are pregnant, might become pregnant, or are breast-feeding, consult a doctor, as they may be able to diagnose you out of the same way. It is important to avoid alcohol while taking Orlistat as it may cause side effects in some patients. Therefore, avoid alcohol while taking Orlistat as it may cause unpleasant side effects in your health.
PrecautionsTake as directed by your doctor.
You can buy Orlistat (Xenical/Alli) as an over-the-counter alternative to Wegovy in the UK.
However, Orlistat is a very different type of weight-loss medication, and research suggests it’s not as effective as Wegovy in supporting weight loss.
Wegovy and Orlistat are weight-loss medications approved for use in the UK. However, they are different medications with distinct dosing schedules, costs, and mechanisms of action on the body.
Orlistat is a lipase inhibitor. Lipases are gut enzymes that break down fat from food, enabling the gut to transport fat into the body to be burnt for energy or stored in our fat cells for later use.
Orlistat blocks lipases, preventing some of the dietary fat from our meals from being digested. This leads to fewer calories being absorbed, which can support weight loss.
Orlistat is a prescription medication produced by two pharmaceutical companies in the UK:
Wegovy is a weight-loss jab manufactured by Novo Nordisk. It’s a weekly weight-loss injection with semaglutide as the active ingredient.
Semaglutide is a that helps reduce hunger and appetite, allowing you to eat fewer calories, lose weight, and manage your blood sugar levels.
Wegovy is approved in the UK for individuals living with obesity to help them eat fewer calories and lose weight.
The over-the-counter version of Orlistat will cost around £18 a month, so it’s a very affordable medication.
In comparison, buying Wegovy and the injectable pens required for four weeks from Second Nature will cost £229 a month, rising to £299.
Orlistat is an affordable medication that is generally well-tolerated. However, it’s less effective than Wegovy. Wegovy is twice as effective as Orlistat for weight loss after one year.
So, if you’re looking for the most affordable weight-loss pill you can purchase over the counter, then Orlistat could be an option.
However, if you have a higher budget and are looking for the most effective weight-loss injection in the UK, semaglutide is a better choice.
Semaglutide is designed as an additional tool for weight management and, in most cases, shouldn’t be considered a lifelong medication.
Instead, it should be used to help you kickstart your weight loss and healthy journey while you commit to living a healthier lifestyle.
Ideally, we’d be able to lose weight without medication and lifestyle changes would be enough to support weight loss in the long term.
We’d generally recommend trying Second Nature’s before considering a weight-loss jab.
Changing your habits is the most sustainable way to achieve long-term weight loss, and it’s also less expensive.
At Second Nature, we’ve been trusted by the NHS since 2017 to support people with type 2 diabetes and obesity to lose weight, manage their blood sugar levels, and lead healthier lifestyles for the long term.
In 2022, the NHS in the BMJ that compared the weight loss outcomes of five providers in the National Diabetes Prevention Programme.
Second Nature was more than twice as effective at supporting weight loss than the other four providers.
However, if you’ve decided to try semaglutide (when it’s available) but need support in making positive changes to your lifestyle, Second Nature could be an option for you. But it’s worth noting that we have strict eligibility criteria.
Second Nature has been in medicine for more than 7 years and offers a range of approved weight-loss medications.The company that best fits your needs is Second Nature.
Featured Product in Allergen Diet– Allergen Diet contains the active ingredient Orlistat, which is the only weight loss medication approved by the FDA. It works to help you lose extra pounds and maintain an active and healthy body weight by preventing the absorption of dietary fats.
Orlistat’s Benefits for You– The active ingredient in Allergen Diet, Orlistat, is also FDA-approved to treat oily skin or oily skin, including oily skin with at least one oily area around the main body parts.
How Allergen Diet Works– Allergen Diet works by blocking the fat from your diet from being absorbed, which prevents it from being broken down and absorbed again. It is absorbed into your body more efficiently than the fat from food. It is absorbed by your intestines and is then released once or twice a day. This way, it doesn’t matter how much you eat if the fat is absorbed.
Allergen Diet Precautions and Side Effects– Allergen Diet is not recommended for use in children under 18 years. It should be used with caution in patients with certain medical conditions (such as severe obesity or diabetes). Allergen Diet can cause gastrointestinal side effects (such as oily or fatty stools), including diarrhea, flatulence, and gas.
Contraindications– Allergen Diet is contraindicated in people with a history of blood clots, severe liver disease, or a history of pancreatitis. Allergen Diet may increase your risk of developing serious or life-threatening side effects, including:
Possible Side Effects– Common side effects include oily skin, skin changes, and oily or fatty stools.
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